Ampullosporin, a New Peptaibol-type Antibiotic from Sepedonium ampullospomm HKI-0053 with Neuroleptic Activity in Mice

MICHAEL RITZAU; STEPHAN HEINZE; KLAUSJÜRGEN DORNBERGER; ALBRECHT BERG; WERNER FLECK; BRIGITTE SCHLEGEL; ALBERT HÄRTL; UDO GRÄFE

doi:10.7164/antibiotics.50.722

Ampullosporin, a New Peptaibol-type Antibiotic from Sepedonium ampullospomm HKI-0053 with Neuroleptic Activity in Mice

MICHAEL RITZAU, STEPHAN HEINZE, KLAUSJÜRGEN DORNBERGER, ALBRECHT BERG, WERNER FLECK, BRIGITTE SCHLEGEL, ALBERT HÄRTL, UDO GRÄFE

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JOURNAL FREE ACCESS

1997 Volume 50 Issue 9 Pages 722-728

DOI https://doi.org/10.7164/antibiotics.50.722

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Abstract

Ampullosporin (I; Ac-Trp-Ala-Aib-Aib-Leu-Aib-Gln-Aib-Aib-Aib-Gln-Leu-Aib-Gln-Leuol) was isolated from the mycelium of Sepedonium ampullospomm as a new 15-membered peptaibol-type antibiotic. The structure was determined by mass spectrometric and two-dimensional NMR experiments. Ampullosporin displays narrow-spectrum antibacterial and antifungal activity, induces pigment formation by Phoma destructive, causes hypothermia and decreased spontaneous locomotor activity in mice in dosages > 1 mg/kg.

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