Micacocidin A, B and C, Novel Antimycoplasma Agents from Pseudomonas sp. II. Structure Elucidation

SHINOBU KOBAYASHI; HIROSHI NAKAI; YUJI IKENISHI; WEI-YIN SUN; MAMORU OZAKI; YOSHIO HAYASE; REIJI TAKEDA

doi:10.7164/antibiotics.51.328

Micacocidin A, B and C, Novel Antimycoplasma Agents from Pseudomonas sp.

II. Structure Elucidation

SHINOBU KOBAYASHI, HIROSHI NAKAI, YUJI IKENISHI, WEI-YIN SUN, MAMORU OZAKI, YOSHIO HAYASE, REIJI TAKEDA

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JOURNAL FREE ACCESS

1998 Volume 51 Issue 3 Pages 328-332

DOI https://doi.org/10.7164/antibiotics.51.328

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Abstract

Metal-containing novel heterocyclic antibiotics, micacocidin A (1), B (2), and C (3) have been isolated from the culture filtrate of Pseudomonas sp. No. 57-250. The structure and absolute configuration of micacocidin A, an octahedral Zn²⁺ complex, was determined by X-ray crystallographic analysis. And then, the structures of the two congeners, micacocidin B (Cu²⁺ complex) and C (Fe³⁺ complex) were investigated by employing one dimensional and two dimensional homonuclear and heteronuclear NMR spectroscopies and mass spectrometry.

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