CONTROLLED BIOSYNTHESIS OF NEOVIRIDOGRISEINS, NEW HOMOLOGUES OF VIRIDOGRISEIN IV. <i>IN VITRO</i> SYNERGISM BETWEEN NEOVIRIDOGRISEIN II AND THE ANTIBIOTICS OF THE MIKAMYCIN A GROUP

YASUSHI OKUMURA; MICHIKO SAKAMOTO; TOMOKO TAKEI; TOMOYUKI ISHIKURA; YASUO FUKAGAWA

doi:10.7164/antibiotics.32.1130

CONTROLLED BIOSYNTHESIS OF NEOVIRIDOGRISEINS, NEW HOMOLOGUES OF VIRIDOGRISEIN

IV. IN VITRO SYNERGISM BETWEEN NEOVIRIDOGRISEIN II AND THE ANTIBIOTICS OF THE MIKAMYCIN A GROUP

YASUSHI OKUMURA, MICHIKO SAKAMOTO, TOMOKO TAKEI, TOMOYUKI ISHIKURA, YASUO FUKAGAWA

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JOURNAL FREE ACCESS

1979 Volume 32 Issue 11 Pages 1130-1136

DOI https://doi.org/10.7164/antibiotics.32.1130

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Abstract

Neoviridogrisein II is a homologue of viridogriscin in which the hydroxyproline residue is replaced by proline. Neoviridogrisein II proved to be more active than the parent antibiotic against Gram-positive bacteria and Mycoplasma species. When neoviridogrisein II or viridogrisein was combined with griseoviridin, a non-peptidyl macrocyclic lactone, synergism was observed: maximum synergistic effect was observed for a combination ratio that depended on the test bacterium used. Neoviridogrisein II also exerted synergism when combined with mikamycin A and A-2315A.

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