The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
N-DEMETHYLVANCOMYCIN, A NOVEL ANTIBIOTIC PRODUCED BY A STRAIN OFNOCARDIA ORIENTALIS
TAXONOMY AND FERMENTATION
LAVERNE D. BOECKFREDERICK P. MERTZROBERT K. WOLTERCALVIN E. HIGGENS
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JOURNAL FREE ACCESS

1984 Volume 37 Issue 5 Pages 446-453

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Abstract

A novel vancomycin analog, N-demethylvancomycin, is produced by a soil isolate collected in Yucatan, Mexico. Taxonomic studies indicated this microorganism, designated NRRL 15232, is a strain of Nocardia orientalis. Unlike some glycopeptide antibiotics, virtually none of the N-demethylvancomycin synthesized remained bound to the cells of the producing culture. Antibiotic production was markedly depressed by the addition of orthophosphate to the fermentation medium. Enrichment of the medium with tyrosine, p-hydroxyphenylglycine, p-hydroxyphenylglyoxylic acid, or leucine, all putative precursors of the aglycone, stimulated the biosynthesis of N-demethylvancomycin.

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© Japan Antibiotics Research Association
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