AZINOMYCINS A AND B, NEW ANTITUMOR ANTIBIOTICS I. PRODUCING ORGANISM, FERMENTATION, ISOLATION, AND CHARACTERIZATION

KATSUHIKO NAGAOKA; MASARU MATSUMOTO; JUNJI OONO; KOUICHI YOKOI; SEIJI ISHIZEKI; TOSHIAKI NAKASHIMA

doi:10.7164/antibiotics.39.1527

AZINOMYCINS A AND B, NEW ANTITUMOR ANTIBIOTICS

I. PRODUCING ORGANISM, FERMENTATION, ISOLATION, AND CHARACTERIZATION

KATSUHIKO NAGAOKA, MASARU MATSUMOTO, JUNJI OONO, KOUICHI YOKOI, SEIJI ISHIZEKI, TOSHIAKI NAKASHIMA

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JOURNAL FREE ACCESS

1986 Volume 39 Issue 11 Pages 1527-1532

DOI https://doi.org/10.7164/antibiotics.39.1527

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Abstract

A strain of Streptomyces griseofuscus S42227 (FERM P-8443) was found to produce new antitumor antibiotics, called azinomycins A and B. The molecular formulas of azinomycins A and B were determined as C₃₀H₃₃N₃O₁₀ and C₃₁H₃₃N₃O₁₁, respectively. They were active against Gram-positive bacteria, Gram-negative bacteria and L5178Y cells in tissue culture.

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