Glucolipsin A and B, Two New Glucokinase Activators Produced by Streptomyces purpurogeniscleroticus and Nocardia vaccinii

JINGFANG QIAN-CUTRONE; T. UEKI; STELLA HUANG; KASIM A. MOOKHTIAR; REGINA EZEKIEL; STEVEN S. KALINOWSKI; KAREN S. BROWN; JERZY GOLIK; SUSAN LOWE; DOLORES M. PIRNIK; ROBERT HUGILL; JUDY A. VEITCH; STEVEN E. KLOHR; JEFFREY L. WHITNEY; SUSAN P. MANLY

doi:10.7164/antibiotics.52.245

Glucolipsin A and B, Two New Glucokinase Activators Produced by Streptomyces purpurogeniscleroticus and Nocardia vaccinii

JINGFANG QIAN-CUTRONE, T. UEKI, STELLA HUANG, KASIM A. MOOKHTIAR, REGINA EZEKIEL, STEVEN S. KALINOWSKI, KAREN S. BROWN, JERZY GOLIK, SUSAN LOWE, DOLORES M. PIRNIK, ROBERT HUGILL, JUDY A. VEITCH, STEVEN E. KLOHR, JEFFREY L. WHITNEY, SUSAN P. MANLY

Author information

JINGFANG QIAN-CUTRONE
Bristol-Myers Squibb Pharmaceutical Research Institute
T. UEKI
Bristol-Myers Squibb Pharmaceutical Research Institute
STELLA HUANG
Bristol-Myers Squibb Pharmaceutical Research Institute
KASIM A. MOOKHTIAR
Bristol-Myers Squibb Pharmaceutical Research Institute
REGINA EZEKIEL
Bristol-Myers Squibb Pharmaceutical Research Institute
STEVEN S. KALINOWSKI
Bristol-Myers Squibb Pharmaceutical Research Institute
KAREN S. BROWN
Bristol-Myers Squibb Pharmaceutical Research Institute
JERZY GOLIK
Bristol-Myers Squibb Pharmaceutical Research Institute
SUSAN LOWE
Bristol-Myers Squibb Pharmaceutical Research Institute
DOLORES M. PIRNIK
Bristol-Myers Squibb Pharmaceutical Research Institute
ROBERT HUGILL
Bristol-Myers Squibb Pharmaceutical Research Institute
JUDY A. VEITCH
Bristol-Myers Squibb Pharmaceutical Research Institute
STEVEN E. KLOHR
Bristol-Myers Squibb Pharmaceutical Research Institute
JEFFREY L. WHITNEY
Bristol-Myers Squibb Pharmaceutical Research Institute
SUSAN P. MANLY
Bristol-Myers Squibb Pharmaceutical Research Institute

JOURNAL FREE ACCESS

1999 Volume 52 Issue 3 Pages 245-255

DOI https://doi.org/10.7164/antibiotics.52.245

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Abstract

During the screening of the natural products for their ability to increase the activity of glucokinase by relieving inhibition by long chain fatty acyl CoA esters (FAC), two novel compounds, glucolipsin A (1) and B (2) were isolated from the butanol extracts of Streptomyces purpurogeniscleroticus WC71634 and Nocardia vaccinii WC65712, respectively. The structures of these two compounds were established by spectroscopic methods and chemical degradation. Glucolipsin A (1) and B (2) relieved the inhibition of glueokinase by FAC with RC₅₀ values of 5.4 and 4.6μM.

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