Cephaibols, New Peptaibol Antibiotics with Anthelmintic Properties from Acremonium tubakii DSM 12774

MATTHIAS SCHIELL; JOACHIM HOFMANN; MICHAEL KURZ; FRANK RAINER SCHMIDT; LÁSZLÓ VÉRIEST; MARTIN VOGEL; JOACHIM WINK; GERHARD SEIBERT

doi:10.7164/antibiotics.54.220

Cephaibols, New Peptaibol Antibiotics with Anthelmintic Properties from Acremonium tubakii DSM 12774

MATTHIAS SCHIELL, JOACHIM HOFMANN, MICHAEL KURZ, FRANK RAINER SCHMIDT, LÁSZLÓ VÉRIEST, MARTIN VOGEL, JOACHIM WINK, GERHARD SEIBERT

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JOURNAL FREE ACCESS

2001 Volume 54 Issue 3 Pages 220-233

DOI https://doi.org/10.7164/antibiotics.54.220

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Abstract

Two groups of new peptaibol-type antibiotics termed cephaibols have been isolated from the fungus Acremonium tubahii, DSM 12774. These 16- or 17-unit straight-chain peptides, whose structures were characterized by amino acid analyses, 2-D NMR experiments, and by mass spectrometric sequencing, have a high content of the unusual amino acids aminoisobutyric acid and isovaline. The principal constituent of the novel peptaibol mixture is cephaibol A, which is formed in abundance in cultures of the wild strain. The striking biological property of cephaibol A is its pronounced anthelmintic action and activity against ectoparasites.

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