Ripromycin and Other Polycyclic Macrolactams from Streptomyces sp. Tü 6239 Taxonomy, Fermentation, Isolation and Biological Properties

MARCELO BERTASSO; MEIKE HOLZENKÄMPFER; AXEL ZEECK; ERKO STACKEBRANDT; WINFRIED BEIL; HANS-PETER FIEDLER

doi:10.7164/antibiotics.56.364

Ripromycin and Other Polycyclic Macrolactams from Streptomyces sp. Tü 6239

Taxonomy, Fermentation, Isolation and Biological Properties

MARCELO BERTASSO, MEIKE HOLZENKÄMPFER, AXEL ZEECK, ERKO STACKEBRANDT, WINFRIED BEIL, HANS-PETER FIEDLER

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JOURNAL FREE ACCESS

2003 Volume 56 Issue 4 Pages 364-371

DOI https://doi.org/10.7164/antibiotics.56.364

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Abstract

Strain Tü 6239 was isolated from a soil sample collected in Brazil and determined as a new species of the genus Streptomyces. In the course of our HPLC-diode array screening program three metabolites were detected in the culture filtrate and mycelium extracts of strain Tü 6239. They were characterised as members of the macrolactam group, the new compound ripromycin (1), the previously described ikarugamycin (2) and a new derivative of it, ikarugamycin epoxide (3). They show antibiotic activities against Gram-positive bacteria and cytostatic effects to various human tumor cell lines.

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