New Beauvericins, Potentiators of Antifungal Miconazole Activity, Produced by Beauveria sp. FKI-1366 I. Taxonomy, Fermentation, Isolation and Biological Properties

TAKASHI FUKUDA; MASAYOSHI ARAI; YUICHI YAMAGUCHI; ROKUROU MASUMA; HIROSHI TOMODA; SATOSHI OMURA

doi:10.7164/antibiotics.57.110

New Beauvericins, Potentiators of Antifungal Miconazole Activity, Produced by Beauveria sp. FKI-1366

I. Taxonomy, Fermentation, Isolation and Biological Properties

TAKASHI FUKUDA, MASAYOSHI ARAI, YUICHI YAMAGUCHI, ROKUROU MASUMA, HIROSHI TOMODA, SATOSHI OMURA

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JOURNAL FREE ACCESS

2004 Volume 57 Issue 2 Pages 110-116

DOI https://doi.org/10.7164/antibiotics.57.110

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Abstract

Three new beauvericins, designated beauvericins D, E and F, were isolated along with known beauvericin and beauvericin A, from the culture of Beauveria sp. FKI-1366 by solvent extraction. ODS column chromatography and HPLC. These compounds potentiate miconazole activity against not only wild Candida albicans but also fluconazole resistant C. albicans. Beauvericins D and E decreased the IC₅₀ value of miconazole against fluconazole resistant C. albicans from 1.3μM to 0.25 and 0.31μM, respectively.

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