Abstract

Cardiac lymphomas are extremely rare and have poor prognoses. Currently, there are no established guidelines for treatment and the main approaches include surgery, chemotherapy (CHT), possibly combined with radiotherapy (RT), and autologous stem cell transplantation (ASCT). RT’s role is controversial and is not considered a standard approach. We describe the case of a patient diagnosed with cardiac lymphoblastic B- cell lymphoma/ acute Lymphoblastic B-cell leukemia and successfully treated with a multimodality approach, including CHT, RT, and ASCT. In particular, the patient was referred to magnetic resonance-guided RT (MRgRT), currently the most advanced available technology in the RT field, which maximizes therapeutic efficacy by exploiting the best soft-tissue resolution of the magnetic resonance images and efficient gating protocols during treatment delivery.